Jacob Murphy and Alexander Isak each scored twice and Joelinton added another as Newcastle scythed through a fragile visiting defence lacking confidence from last week's defeat against Bournemouth.
Harry Kane pulled one back in the second half but Callum Wilson added a sixth shortly after coming off the bench to complete the rout.
The embarrassing defeat is a significant blow to Spurs' dwindling Champions League hopes while the victory puts the Magpies in a commanding position as they climb to third.
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